The emergence of regional governments in Europe points out two questions on party government and cabinet stability. First, whether new regional governments share the same patterns of stability as national governments (despite of the differences that could exist between both levels). Second, whether explanations for national cabinet stability also works in regional governments. The paper have two aims. First, to measure the degree of ministerial turnout in regional executives and to compare it to the national level. Second, to explain why some regional ministers stay longer in power than other. In this sense we aim to test the impact of institutional factors on ministerial turnout: type of government; number of parties in cabinet; parliamentary and executive presence of non state wide parties; “multilevel congruence” in government; and the institutional design and, specifically, the differences in early dissolution powers. Our main hypothesis is that regional political settings that foster cabinet stability also favour ministerial stability. To test our hypothesis, we have collected data from the whole regional executives that have taken place in Spain from 1980 to 2011. In almost thirty years there have been 122 legislative mandates in the 17 Spanish regions, and more than 1200 regional cabinet posts. This data will allow us to use explanatory inference to test our hypothesis.